Passion flower and Kava

[Akava]

Is this allowed? One member said yes but I want to be sure,

also gonna call in @infraredz for his take

 

[kavadude]

I'd advise against it as desmethoxyyanognin (the major kavalactone that we never talk about) is also a MAO inhibitor

 

[endwatcher]

I do it all the time, and love the effects.
Passion flower is also a mao inhibitor
But as far as I've looked, havent seen anything bad about its use with Kava.

Its a great combo, might I add; it has quite the synergy

 

[Gourmet Hawaiian Kava]

I personally like to stick with tradition and the tradition is that you do not add anything to kava except water.
I am not saying it is bad but I do know that there are some things that kava is known to have bad effects with, I would not want to find out down the road that Passion Flower is one of them, for example there is a medicine, I forgot the name but it is like a strong Tylenol and that is known to cause problems when you drink kava and take that pill. This is just my view, aloha.

Chris

 

[Akava]

Interesting, thanks for the advice everyone.
@infraredz ...? We need the kava doctor!

 

[TidyMinion]

@endwatcher Not familiar with passion flower but am interested in this synergy. I see Gaia Herbs has liquid capsules on Amazon well-priced and it's a pretty trustworthy brand. Is this like what you are using? I understand the idea that we want to keep this forum mainly kava related so feel free to PM me with any info if you don't post here, if you wouldn't mind. Thanks!

 

[infraredz]

Yeah, Desmethoxy-yangonin and methysiticin are reversible MAO-B inhibitors, but don't seem to have a high enough affinity to be of any clinical significance in regard to mixing it with passion flower. Mixing it with something like Syrian Rue might be a different story, but unless there's some idiosyncrasies going on with you, there shouldn't be an issue.

"The two most potent kava pyrones, desmethoxyyangonin and (+/-)-methysticin displayed a competetive inhibition pattern with mean Ki 0.28 microM and 1.14 microM respectively."
[http://www.ncbi.nlm.nih.gov/pubmed/9832350]


Regarding Ki, here's an excerpt from that older "how it works" thread regarding affinities (in this case referring to yangonin and cannabinoids):

"Also, and more importantly, the affinity is in the micromolar range vs. the nanomolar range which is more common for actual cannibinoids (ie. THC).
THC has an Ki of 10nM for CB1. By comparison, the Ki of Yangonin is 0.72 μM.

Keep in mind there are 1000 micromoles (μM) to 1 nanomole (nM)."

Here's a good reference if anyone is interested:
http://www.bindingdb.org/bind/index.jsp

 

[infraredz]

Also, DMY is found in exceedingly low concentrations in kava (as far as I remember). Usually it is the last or next-to-last lactone in chemotypes