I generally drink kava nightly, for those of you who don't know I have a stressful job as a Doc and have asperger's, ya it's like that. It's pretty mild, I obsessive, hyper and pretty much a giant kid lol. I also tend to get obssesed with things, like a particular game or watching movies or patients etc.. kava is becoming that. Recently I have begun daytime drinking, and I have to say it has made life that much easier although I have this guilty feeling about using it while working (small amounts), while I find I actually think much clearer being "on" anything makes me concerned. Does anyone here work while have kava? is this something you guys avoid, any detriments I should know about? I have a pretty good grasp of kava and it's pharmacology and it's effects, I guess I'm looking for experienced advice and wondering if I'm venturing into territory of no-no.
On a side note, more anti-cancer news for kava drinkers
Biochem Biophys Res Commun. 2012 Aug 3;424(3):488-92. Epub 2012 Jul 3.Inhibition of mitogen activated protein kinases increases the sensitivity of A549 lung cancer cells to the cytotoxicity induced by a kava chalcone analog.Warmka JK, Solberg EL, Zeliadt NA, Srinivasan B, Charlson AT, Xing C, Wattenberg EV.SourceDivision of Environmental Health Sciences, School of Public Health, University of Minnesota, MMC 807, 420 Delaware Street SE, Minneapolis, MN 55455, USA.AbstractWe are interested in investigating the biological activity of chalcones, a major class of compounds found in the beverage kava, in order to develop potent and selective chemopreventive candidates. Consumption of kava in the South Pacific Islands is inversely correlated with cancer incidence, even among smokers. Accordingly, chalcones have anti-cancer activities in animal and cell culture models. To investigate signaling pathways that affect chalcone action we studied a potent analog, (E)-3-(3-hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (chalcone-24). Chalcone-24 was selected from a series of chalcone analogs that were synthesized based on the structures derived from flavokawain compounds found in kava, and screened in A549 lung cancer cells for induction of cytotoxicity and inhibition of NF-κB, a transcription factor associated with cell survival. Incubation of A549 cells with chalcone-24 resulted in a dose-dependent inhibition of cell viability, inhibition of NF-κB, activation of caspases, and activation of extracellular signal regulated kinase 1/2 (ERK1/2) and c-Jun N-terminal kinase (JNK); ERK1/2 and JNK are mitogen activated protein kinases that play central roles in regulating cell fate. Pharmacological inhibitors of ERK1/2 or JNK increased the sensitivity of A549 cells to chalcone-24-induced cytotoxicity, without affecting NF-κB or caspase activity. These results will help refine the synthesis of chalcone analogs to maximize the combination of actions required to prevent and treat cancer.
tis an analog but it is naturally occuring in kava at lower doses. This plant also inhibits colon cancer it seems. I don't think there is a compound on earth that is both effective and non-addictive in anyway, it's quite the find.
On a side note, more anti-cancer news for kava drinkers
Biochem Biophys Res Commun. 2012 Aug 3;424(3):488-92. Epub 2012 Jul 3.Inhibition of mitogen activated protein kinases increases the sensitivity of A549 lung cancer cells to the cytotoxicity induced by a kava chalcone analog.Warmka JK, Solberg EL, Zeliadt NA, Srinivasan B, Charlson AT, Xing C, Wattenberg EV.SourceDivision of Environmental Health Sciences, School of Public Health, University of Minnesota, MMC 807, 420 Delaware Street SE, Minneapolis, MN 55455, USA.AbstractWe are interested in investigating the biological activity of chalcones, a major class of compounds found in the beverage kava, in order to develop potent and selective chemopreventive candidates. Consumption of kava in the South Pacific Islands is inversely correlated with cancer incidence, even among smokers. Accordingly, chalcones have anti-cancer activities in animal and cell culture models. To investigate signaling pathways that affect chalcone action we studied a potent analog, (E)-3-(3-hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (chalcone-24). Chalcone-24 was selected from a series of chalcone analogs that were synthesized based on the structures derived from flavokawain compounds found in kava, and screened in A549 lung cancer cells for induction of cytotoxicity and inhibition of NF-κB, a transcription factor associated with cell survival. Incubation of A549 cells with chalcone-24 resulted in a dose-dependent inhibition of cell viability, inhibition of NF-κB, activation of caspases, and activation of extracellular signal regulated kinase 1/2 (ERK1/2) and c-Jun N-terminal kinase (JNK); ERK1/2 and JNK are mitogen activated protein kinases that play central roles in regulating cell fate. Pharmacological inhibitors of ERK1/2 or JNK increased the sensitivity of A549 cells to chalcone-24-induced cytotoxicity, without affecting NF-κB or caspase activity. These results will help refine the synthesis of chalcone analogs to maximize the combination of actions required to prevent and treat cancer.
tis an analog but it is naturally occuring in kava at lower doses. This plant also inhibits colon cancer it seems. I don't think there is a compound on earth that is both effective and non-addictive in anyway, it's quite the find.
