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Kava Fact of the Day Flavokavain A shown to help treat chemoresistant lung cancer.

The Kap'n

The Groggy Kaptain (40g)
KavaForums Founder
Flavokavain-A: The ability to treat drug resistant lung cancer.

Lung cancer is a leading cause of cancer related deaths. Standard surgery and radiotherapies have worked well, however a need for different compounds has risen. In some situations, surgery or radiotherapy is not possible, leaving only chemo as the major treatment option. Chemoresistance can comes into play in this situation. Whenever a cancer changes and adapts to evade or cope with the presence of therapeutics it is known as chemoresistance. One of the mechanisms of this resistance is known as permeability-glycoprotein (P-gp) mediated drug resistance. P-gp resistance reversal allows for the cancer to be re-sensitized to standard therapeutics. FKA downregulates P-gb expression in drug resistant cancer cells (A549/T cells), and also induces apoptosis (cellular death) in those same cells. Drugs have been created to address this issue in the past, however first and second generations of these drugs failed in clinical tests due to undesired side effects and toxicity issues. Flavokavain A was shown to have none of these toxicity issues. FKA was tested directly on liver cells and it was found it exerted no obvious hepatoxicity. FKA is suggested in this study to be a possible candidate for the treatment of drug-resistant lung cancer.



Li, J., & Lei, Z. (2019). Activity and mechanism of flavokawain A in inhibiting P-glycoprotein expression in paclitaxel resistance of lung cancer. Oncology Letters, 19(1), 379-387. doi:10.3892/ol.2019.11069

Full study is available to view. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923923/)
 

Alia

'Awa Grower/Collector
By far the research on kava constituents and cancers has been prevention.
This clearly shows that after the fact treatment also can work.
Ideally all of us who regularly consume kava are in the prevention mode.
noun --the action of stopping something from happening or arising.
 

The Kap'n

The Groggy Kaptain (40g)
KavaForums Founder
By far the research on kava constituents and cancers has been prevention.
This clearly shows that after the fact treatment also can work.
Ideally all of us who regularly consume kava are in the prevention mode.
noun --the action of stopping something from happening or arising.
Truly I'm on the same page and why isn't there a special committee for all of this, lol. I'd say that paper has quite a bit of weight considering all the drugs that have been created to address this specific cancer issue and still couldn't pass the bar for being too toxic. FkA, no observed toxicity. That's huge if you ask me.
 

Zaphod

Kava Lover
Flavokavain-A: The ability to treat drug resistant lung cancer.

Lung cancer is a leading cause of cancer related deaths. Standard surgery and radiotherapies have worked well, however a need for different compounds has risen. In some situations, surgery or radiotherapy is not possible, leaving only chemo as the major treatment option. Chemoresistance can comes into play in this situation. Whenever a cancer changes and adapts to evade or cope with the presence of therapeutics it is known as chemoresistance. One of the mechanisms of this resistance is known as permeability-glycoprotein (P-gp) mediated drug resistance. P-gp resistance reversal allows for the cancer to be re-sensitized to standard therapeutics. FKA downregulates P-gb expression in drug resistant cancer cells (A549/T cells), and also induces apoptosis (cellular death) in those same cells. Drugs have been created to address this issue in the past, however first and second generations of these drugs failed in clinical tests due to undesired side effects and toxicity issues. Flavokavain A was shown to have none of these toxicity issues. FKA was tested directly on liver cells and it was found it exerted no obvious hepatoxicity. FKA is suggested in this study to be a possible candidate for the treatment of drug-resistant lung cancer.



Li, J., & Lei, Z. (2019). Activity and mechanism of flavokawain A in inhibiting P-glycoprotein expression in paclitaxel resistance of lung cancer. Oncology Letters, 19(1), 379-387. doi:10.3892/ol.2019.11069

Full study is available to view. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923923/)
What I am taking away from all this anti-cancer kava research is that I need to drink more tudei...:bookworm:
 
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