kava interactions?

[Bdub1992]

Hi, i take baclofen and like kava. I have read that certain herbs like ginseng will antagonize my baclofen. Would kava be similar to ginseng in this matter?

 

[The Kap'n]

Hi, i take baclofen and like kava. I have read that certain herbs like ginseng will antagonize my baclofen. Would kava be similar to ginseng in this matter?

Not a doctor, so I have to lay down that disclaimer.

From what I can see (https://go.drugbank.com/drugs/DB00181) baclofen would not interact with kava. Baclofen's main target of action is GABA-B, which isn't an area we see active with kava. Kava also likely doesn't interact pharmacokinetically by way of enzymes, as baclofen is metabolized in the liver by way of deamination, and not by way of catalyzation through CYP enzymes.

Should be good to go, but as always, bounce it off your doc.