new kava discoveries..
- Thread starter TheKavaSociety
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Wow this is big news, nice find!
verticity
I'm interested in things
Interesting. Here is the paper. (It's not copyrighted).
lol...They tested the effect of kava on worms (and also mutant worms...). The results are unexpected because according to the paper:
"The inhibitory-excitatory balance at the C elegans NMJ is maintained by the opposing actions of GABA and ACh. When the level of ACh signaling (excitation) is substantially greater than the level of GABA transmission (inhibition) at the C elegans NMJ, this results in muscle hypercontraction, which can manifest as a convulsion or paralysis. In our study, we showed that treatment of C elegans with kavalactones resulted in convulsions and paralysis (Figure 1). We hypothesized that these responses are indicative of elevated or prolonged ACh transmission at the NMJ."
Kava is normally thought of as acting in a GABAergic way, so this result is the opposite of what one would expect.
Interestingly, they noted that kavain has a different effect on worms than the other KLs.
lol...They tested the effect of kava on worms (and also mutant worms...). The results are unexpected because according to the paper:
"The inhibitory-excitatory balance at the C elegans NMJ is maintained by the opposing actions of GABA and ACh. When the level of ACh signaling (excitation) is substantially greater than the level of GABA transmission (inhibition) at the C elegans NMJ, this results in muscle hypercontraction, which can manifest as a convulsion or paralysis. In our study, we showed that treatment of C elegans with kavalactones resulted in convulsions and paralysis (Figure 1). We hypothesized that these responses are indicative of elevated or prolonged ACh transmission at the NMJ."
Kava is normally thought of as acting in a GABAergic way, so this result is the opposite of what one would expect.
Interestingly, they noted that kavain has a different effect on worms than the other KLs.
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SelfBiasResistor
Persist for Resistance!
So an increase in acetylcholine activity could be at least partially responsible for the mental clarity kava offers in comparison to other intoxicants?
verticity
I'm interested in things
If it does the same thing in the brains of animals with brains, yes.
verticity
I'm interested in things
There was this paper:
African Journal of Pharmacy and Pharmacology Vol. 4(11), pp. 823-828, November 2010
which showed that the activity of the enzyme that breaks down acetylcholine showed some variation in the brains of rats given kava. The activity varied over time, possibly suggesting an explanation for "reverse tolerance".
African Journal of Pharmacy and Pharmacology Vol. 4(11), pp. 823-828, November 2010
which showed that the activity of the enzyme that breaks down acetylcholine showed some variation in the brains of rats given kava. The activity varied over time, possibly suggesting an explanation for "reverse tolerance".
Zaphod
Kava Lover
Yes, two intelligent cuties wanting to research Kava is a rare find indeed! I wonder why they choose kava? My first question would be do they partake of our beloved beverage? The second is when do they plan on doing human studies and where do I sign up? Inquiring minds want to know!
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