The Kap'n The Groggy Kaptain (40g) KavaForums Founder May 11, 2013 #2 Yes! I completely agree with this logic. I've experienced this myself a number of times.
Buddhacide Kava Enthusiast May 11, 2013 #3 Assuming individual lactones ultimately affect different receptors and produce different effects (ie kavain vs DHM etc...), then it would make sense for tolerances to change as chemotype profiles change.
Assuming individual lactones ultimately affect different receptors and produce different effects (ie kavain vs DHM etc...), then it would make sense for tolerances to change as chemotype profiles change.
