Very interesting

[mlenny]

This says yangonin *protects* against alcoholic liver injury.

Yangonin inhibits ethanol-induced hepatocyte senescence via miR-194/FXR axis - PubMed

Chronic alcohol assumption has been recognized as a major cause of alcoholic liver disease (ALD), which ranges from alcoholic steatohepatitis to fibrosis and hepatocellular carcinoma. Alcoholic liver disease has become the leading cause of liver-related health problem in the world. Herewith...

pubmed.ncbi.nlm.nih.gov

Matthew

 

[The Kap'n]

This says yangonin *protects* against alcoholic liver injury.

Yangonin inhibits ethanol-induced hepatocyte senescence via miR-194/FXR axis - PubMed

Chronic alcohol assumption has been recognized as a major cause of alcoholic liver disease (ALD), which ranges from alcoholic steatohepatitis to fibrosis and hepatocellular carcinoma. Alcoholic liver disease has become the leading cause of liver-related health problem in the world. Herewith...

pubmed.ncbi.nlm.nih.gov

Matthew

Indeed.

Dong, R.; Wang, J.; Gao, X.; Wang, C.; Liu, K.; Wu, J.; Liu, Z.; Sun, H.; Ma, X.; Meng, Q. Yangonin protects
against estrogen-induced cholestasis in a farnesoid X receptor-dependent manner. Eur. J. Pharmacol. 2019,
857, 172461, doi:10.1016/j.ejphar.2019.172461.

Dong, R.; Yang, X.; Wang, C.; Liu, K.; Liu, Z.; Ma, X.; Sun, H.; Huo, X.; Fu, T.; Meng, Q. Yangonin protects
against non-alcoholic fatty liver disease through farnesoid X receptor. Phytomedicine 2019, 53, 134–142,
doi:10.1016/j.phymed.2018.09.006.

Kong, Y., Gao, X., Wang, C., Ning, C., Liu, K., Liu, Z., Sun, H., Ma, X., Sun, P., and Meng, Q. (2018) Protective effects of yangonin
from an edible botanical Kava against lithocholic acid-induced cholestasis and hepatotoxicity. Eur. J. Pharmacol. 824, 64−71.