FKB

[mlenny]

As a percentage, what would be considered a "high" FKB level?

Thanks,
Matthew

 

[The Kap'n]

As a percentage, what would be considered a "high" FKB level?

Thanks,
Matthew

Anything over .5% is generally what would be considered "High"

 

[Palmetto]

While flavokavains are one of the least desirable compounds found in noble kavas (as well as tudeis) they are also possibly the most anticancer compounds in kava.

 

[mlenny]

While flavokavains are one of the least desirable compounds found in noble kavas (as well as tudeis) they are also possibly the most anticancer compounds in kava.

Yeah, I've seen some stuff about that. But, unfortunately, there's at least currently a certain inseparability between "antineoplastic" and "toxic". The difference lies within the dose.

"The dose makes the poison."
-- Paracelsus

 

[The Kap'n]

Unfortunately, there's a certain inseparability between "antineoplastic" and "toxic". The difference lies within the dose.

"The dose makes the poison."
-- Paracelsus

No doubt, and if I had to ask anyone about that specifically, I'd be asking Palmetto. He's quite informed in the world of oncogenesis.

 

[mlenny]

No doubt, and if I had to ask anyone about that specifically, I'd be asking Palmetto. He's quite informed in the world of oncogenesis.

A paper I saw about osteosarcoma (yikes) said FKB was less harmful to tested healthy cells than doxorubicin and I've seen some stuff about preventing lung cancer in smokers. But natural products are difficult to profit from, so I sadly doubt the pharmaceutical industry will be too interested unless they can alter it somehow, which kinda sucks. All about the money...

Matthew

 

[The Kap'n]

A paper I saw about osteosarcoma (yikes) said FKB was less harmful to tested healthy cells than doxorubicin and I've seen some stuff about preventing lung cancer in smokers. But natural products are difficult to profit from, so I sadly doubt the pharmaceutical industry will be too interested unless they can alter it somehow, which kinda sucks. All about the money...

Matthew

We sorta get tied up about FKB, but it's not really even all that toxic. FKA even less so. I suspect FKB was more a culprit in these idiosyncratic cases back in the late 90s to early 2000s due to overconcentration from using non-noble cultivars, but that's a thing of the past these days.


They're really looking closely at flavokavains for chemical structure, and have even synthed some fks with different properties in cancer research. So it's moving, but you're right. It's expensive, and kava is a multicomponent plant which makes the whole deal even more complex.

 

[Palmetto]

Many sarcomas can be tough to treat, other than cutting them out. I had a sick relative that I encouraged to drink tudei and Isa for a couple years as a Hail Mary addition to the chemo. It may have helped, but in the end, it wasn't enough. That is a single anecdote, so definitely not conclusive. Flavokavains seem good at reducing the advance of mutagenesis, but are not a magic bullet once the cancer is advanced. I haven't been keeping up on the kava / cancer literature much since my relative passed away, but I still work in a cancer clinic.

 

[mlenny]

Many sarcomas can be tough to treat, other than cutting them out. I had a sick relative that I encouraged to drink tudei and Isa for a couple years as a Hail Mary addition to the chemo. It may have helped, but in the end, it wasn't enough. That is a single anecdote, so definitely not conclusive. Flavokavains seem good at reducing the advance of mutagenesis, but are not a magic bullet once the cancer is advanced. I haven't been keeping up on the kava / cancer literature much since my relative passed away, but I still work in a cancer clinic.

I find the chemoprotective effect against lung cancer in smokers quite interesting. As I'm sure you know, lung cancer is the most common and one of the deadliest cancers, so it would be great if we could make some advances there.

Yours,
Matthew