I had a terrible experience with a much more mild stimulant, but a bit above caffeine, combined with kava. The MAO-B inhibition is no joke.
Here's how to break it down in the simplest terms I can. Vyvanse releases a lot of dopamine. Monoamine oxidase B (MAO-B) breaks down dopamine so that your brain doesn't fill up with too much of it. One of the kavalactones in kava is a reversible MAO-B inhibitor. That means it stops MAO-B from doing it's job for a while, usually a short while.
If you combine the two, vyvanse releasing all the dopamine, and kava preventing your brain from getting rid of the dopamine, your brain basically just floods with dopamine until one of the two wears off. Too much dopamine can have a wide array of negative health consequences. It also isn't very pleasant from my own experience. Massive anxiety, heart rate increase, jittery mess. My pupils were huge as if I'd taken a ton of MDMA or something.
Anyway, point is, if you stick to only drinking kava on your off days then you'll be fine. The MAO-B inhibition is quickly reversible. So you'll be back to safe levels of MAO-B 4 hours after kava, and back to normal levels 8 hours after kava if this study I'm finding is correct.
Study showing half life, among other things:
http://dmd.aspetjournals.org/content/33/10/1555.full
Wikipedia article on MAO-B, Desmethoxyyangonin (found in kava) is listed as a reversible MAO-B inhibitor:
https://en.wikipedia.org/wiki/Monoamine_oxidase_B
Here's how to break it down in the simplest terms I can. Vyvanse releases a lot of dopamine. Monoamine oxidase B (MAO-B) breaks down dopamine so that your brain doesn't fill up with too much of it. One of the kavalactones in kava is a reversible MAO-B inhibitor. That means it stops MAO-B from doing it's job for a while, usually a short while.
If you combine the two, vyvanse releasing all the dopamine, and kava preventing your brain from getting rid of the dopamine, your brain basically just floods with dopamine until one of the two wears off. Too much dopamine can have a wide array of negative health consequences. It also isn't very pleasant from my own experience. Massive anxiety, heart rate increase, jittery mess. My pupils were huge as if I'd taken a ton of MDMA or something.
Anyway, point is, if you stick to only drinking kava on your off days then you'll be fine. The MAO-B inhibition is quickly reversible. So you'll be back to safe levels of MAO-B 4 hours after kava, and back to normal levels 8 hours after kava if this study I'm finding is correct.
Study showing half life, among other things:
http://dmd.aspetjournals.org/content/33/10/1555.full
Wikipedia article on MAO-B, Desmethoxyyangonin (found in kava) is listed as a reversible MAO-B inhibitor:
https://en.wikipedia.org/wiki/Monoamine_oxidase_B