Acetylcholine esterase

[Gradvlax]

Hi everyone,

I'm in the UK and have just joined as I purchased some Kava extract capsules recently from an Etsy shop - UKMotherNature in Ireland and I think it's a scam - I've had, supposedly, 2400mg of extract today and it's done absolutely nothing. The reason I want to try Kava is because of an acetylcholine brain imbalance and the only other "natural" substance that increases acetylcholine esterase is Coleus Forskolin which works well but can't be taken long term. So I'm looking for tips on where to purchase. Hope to connect with some of you on here.

 

[The Kap'n]

Message the user @Edward. He may have some options on how to get some quality kavas in The United Kingdom.

Here are scientific studies regarding Acetylcholine and kavalactone consumption.

Kautu, Bwarenaba B., Juliana Phillips, Kellie Steele, M. Shawn Mengarelli, and Eric A. Nord. 2017. “A Behavioral Survey of the Effects of Kavalactones on Caenorhabditis Elegans Neuromuscular Transmission.” Journal of Experimental Neuroscience 11 (June): 1179069517705384. https://doi.org/10.1177/1179069517705384.

Meyer, Hans J. 1967. “Pharmacology of Kava.” In Ethnopharmacologic Search for Psychoactive Drugs, 133–40. https://paperpile.com/app/p/d83bf056-04d3-07d4-bc83-394fca156637

Noor, Neveen A. 2010. “Anxiolytic Action and Safety of Kava: Effect on Rat Brain Acetylcholinesterase Activity and Some Serum Biochemical Parameters.” African Journal of Pharmacy and Pharmacology 4 (11): 823–28. https://paperpile.com/app/p/5ce3191c-92bf-0044-a976-a7f4754cb3fe

Sarris, Jerome, Emma LaPorte, and Isaac Schweitzer. 2011. “Kava: A Comprehensive Review of Efficacy, Safety, and Psychopharmacology.” The Australian and New Zealand Journal of Psychiatry 45 (1): 27–35. https://doi.org/10.3109/00048674.2010.522554.

 

[Orz[EST]]

Acetylcholine esterase activity is not rare i the world, especially the mild ones. Would not pick kava for that, thouhg. It has Na+ channel blocking, GABA and (net nonstimulant) dopamine modifying egfects on the foreground AFAIK.

 

[Gradvlax]

Message the user @Edward. He may have some options on how to get some quality kavas in The United Kingdom.

Here are scientific studies regarding Acetylcholine and kavalactone consumption.

Kautu, Bwarenaba B., Juliana Phillips, Kellie Steele, M. Shawn Mengarelli, and Eric A. Nord. 2017. “A Behavioral Survey of the Effects of Kavalactones on Caenorhabditis Elegans Neuromuscular Transmission.” Journal of Experimental Neuroscience 11 (June): 1179069517705384. https://doi.org/10.1177/1179069517705384.

Meyer, Hans J. 1967. “Pharmacology of Kava.” In Ethnopharmacologic Search for Psychoactive Drugs, 133–40. https://paperpile.com/app/p/d83bf056-04d3-07d4-bc83-394fca156637

Noor, Neveen A. 2010. “Anxiolytic Action and Safety of Kava: Effect on Rat Brain Acetylcholinesterase Activity and Some Serum Biochemical Parameters.” African Journal of Pharmacy and Pharmacology 4 (11): 823–28. https://paperpile.com/app/p/5ce3191c-92bf-0044-a976-a7f4754cb3fe

Sarris, Jerome, Emma LaPorte, and Isaac Schweitzer. 2011. “Kava: A Comprehensive Review of Efficacy, Safety, and Psychopharmacology.” The Australian and New Zealand Journal of Psychiatry 45 (1): 27–35. https://doi.org/10.3109/00048674.2010.522554.

Wow! Many thanks for that. I will check them out.

 

[Gradvlax]

Acetylcholine esterase activity is not rare i the world, especially the mild ones. Would not pick kava for that, thouhg. It has Na+ channel blocking, GABA and (net nonstimulant) dopamine modifying egfects on the foreground AFAIK.

Thanks Orz. Yes, @Edward said the same thing. There is so little information about natural acetylcholine esterase boosters. The papers that @The Kap'n shared demonstrate that after an initial increase in AChE it then decreased after 3-4 weeks - so you may be right. My hopes are dashed.