Kava Science Flavokawains A & B potentiate acetaminophen-induced hepatotoxicity in mice

[kavadude]

From October. How did we miss this one?

This in my mind validates the advice to avoid mixing kava with known hepatotoxic substances (most notably ethanol and acetaminophen). Also of note, the mice fed only the extract had no liver lesions of any kind.

Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25185080

 

[sɥɐʞɐs]

There goes my new proprietary blend called wichmanFlavominophenii

 

[verticity]

Kava alone revealed no adverse effects for long-term usage even at a dose of 500 mg/kg bodyweight.

(Emphasis mine)
It's not clear from the abstract if they are dosing the mice with whole kava root, or some kind of exctract, but in either case that is a pretty huge dose, especially if it is extract.

 

[kavadude]

PDF Link: http://libgen.in/scimag/get.php?doi=10.1021/tx5003194

They used Gaia Herbs extract.

 

[verticity]

PDF Link: http://libgen.in/scimag/get.php?doi=10.1021/tx5003194

They used Gaia Herbs extract.

Weird, when I click that link, Malwarebytes Anti-Malware pops up saying it is a "malicious site"

 

[verticity]

But since they were using extract, that really is a huge dose: For an 80 kg human is would be like taking 40 grams of extract.

 

[kavadude]

Okay, I uploaded the PDF to the post.

It certainly is a lot, though I'm not clear on how much of the extract content would be active compounds.

 

[Steve Mariotti]

Some happy fucking mice. Sheesh.

 

[verticity]

Okay, I uploaded the PDF to the post.

It certainly is a lot, though I'm not clear on how much of the extract content would be active compounds.

Yeah, but the point is these mice took this huge dose of kavalactones over the long term with no liver damage. That's good experimental evidence to quote for people who believe kava causes liver damage. Now we have pretty good evidence that, by itself, it doesn't.

 

[verticity]

Some happy fucking mice. Sheesh.

The Tylenol/FKB group was probably not so happy..

 

[kavadude]

Some happy fucking mice. Sheesh.

Xing's emails in the paper, maybe you can be in the next study. Do you have any experience pushing levers or running in wheels?

 

[verticity]

Xing's emails in the paper, maybe you can be in the next study. Do you have any experience pushing levers or running in wheels?

And if you don't mind getting "sacrificed" at the end of the study.