The Nene can give you a daytime buzz but it will also sedate you. It is kind of like the mild sedation I feel with Mapulehu. So if you are having an aggravating day and feeling kind of agitated, then I would I would take some Nene to calm you down and help you focus. Also, it is the most Noble of all the Kavas on Deleted User's list so it may indeed be good medicine to take at night when you have a cold, allergies, or other aggravating minor ailments.