I was reading this today and remembered people talking about feast/famine factor that may protect the native people's liver more.
It seems this may have some merit to it.
http://www.sciencedaily.com/releases/2012/05/120517131703.htm
"In a paper published May 17 in Cell Metabolism, scientists from
Salk's Regulatory Biology Laboratory
reported that mice limited to
eating during an 8-hour period are healthier than mice that eat freely
throughout
the day, regardless of the quality and content of their diet.
The study sought to determine whether obesity
and metabolic diseases
result from a high-fat diet or from disruption of metabolic cycles."
"The Salk study found the body stores fat while eating and starts to burn
fat and breakdown cholesterol into
beneficial bile acids only after a
few hours of fasting. When eating frequently, the body continues to make
and store fat, ballooning fat cells and liver cells, which can result
in liver damage. Under such conditions
the liver also continues to make
glucose, which raises blood sugar levels. Time-restricted feeding, on
the other
hand, reduces production of free fat, glucose and cholesterol
and makes better use of them. It cuts down
fat storage and turns on fat
burning mechanisms when the animals undergo daily fasting, thereby
keeping
the liver cells healthy and reducing overall body fat."
"The daily feeding-fasting cycle activates liver enzymes that breakdown
cholesterol into bile acids, spurring the
metabolism of brown fat -- a
type of "good fat" in our body that converts extra calories to heat.
Thus the body literally
burns fat during fasting. The liver also shuts
down glucose production for several hours, which helps lower blood
glucose. The extra glucose that would have ended up in the blood -- high
blood sugar is a hallmark of diabetes -- is
instead used to build
molecules that repair damaged cells and make new DNA. This helps prevent
chronic inflammation,
which has been implicated in the development of a
number of diseases, including heart disease, cancer, stroke and
Alzheimer's."