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Piper methysticum (kava-kava), and conventional drugs. ... 1) Evaluation of the Effects of Extracts Containing Valeriana officinalis and Piper ...
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Notify me when they use something other than rats, seriously. This has already been studied extensively by the researcher Gurley in human volunteers.
Gurley, B. J., A. Swain, M. A. Hubbard, F. Hartsfield, J. Thaden, D. K. Williams, W. B. Gentry, and Y. Tong. 2008. “Supplementation with Goldenseal (Hydrastis Canadensis), but Not Kava Kava (Piper Methysticum), Inhibits Human CYP3A Activity in Vivo.”
Clinical Pharmacology and Therapeutics 83 (1): 61–69.
https://doi.org/10.1038/sj.clpt.6100222.
Gurley, Bill J., Stephanie F. Gardner, Martha A. Hubbard, D. Keith Williams, W. Brooks Gentry, Ikhlas A. Khan, and Amit Shah. 2005. “In Vivo Effects of Goldenseal, Kava Kava, Black Cohosh, and Valerian on Human Cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 Phenotypes.”
Clinical Pharmacology and Therapeutics 77 (5): 415–26.
https://doi.org/10.1016/j.clpt.2005.01.009.
Gurley, Bill J., Ashley Swain, Gary W. Barone, D. Keith Williams, Philip Breen, C. Ryan Yates, Leslie B. Stuart, Martha A. Hubbard, Yudong Tong, and Sreekhar Cheboyina. 2007. “Effect of Goldenseal (Hydrastis Canadensis) and Kava Kava (Piper Methysticum) Supplementation on Digoxin Pharmacokinetics in Humans.”
Drug Metabolism and Disposition: The Biological Fate of Chemicals 35 (2): 240–45.
https://doi.org/10.1124/dmd.106.012708.
Gurley, Bill J., Ashley Swain, Martha A. Hubbard, D. Keith Williams, Gary Barone, Faith Hartsfield, Yudong Tong, Danielle J. Carrier, Shreekar Cheboyina, and Sunil K. Battu. 2008. “Clinical Assessment of CYP2D6-Mediated Herb-Drug Interactions in Humans: Effects of Milk Thistle, Black Cohosh, Goldenseal, Kava Kava, St. John’s Wort, and Echinacea.”
Molecular Nutrition & Food Research 52 (7): 755–63.
https://doi.org/10.1002/mnfr.200600300.
