“Whereas the neurological benefits of proper kava use appear to be undeniable, particularly in reducing stress and anxiety, there is growing evidence that its consumption could be associated with low incidence of cancer. Furthermore, anti-inflammatory activities have been reported for kava and its compounds, suggesting their potential for the treatment of inflammatory diseases.”
Bian, T.; Corral, P.; Wang, Y.; Botello, J.; Kingston, R.; Daniels, T.; Salloum, R.G.; Johnston, E.; Huo, Z.; Lu, J.; Liu, A.C.; Xing, C. Kava as a Clinical Nutrient: Promises and Challenges. Nutrients 2020, 12, 3044.
www.mdpi.com
(Seriously, if you haven't read the paper above, it's good, and free to everyone)
Bian, T.; Corral, P.; Wang, Y.; Botello, J.; Kingston, R.; Daniels, T.; Salloum, R.G.; Johnston, E.; Huo, Z.; Lu, J.; Liu, A.C.; Xing, C. Kava as a Clinical Nutrient: Promises and Challenges. Nutrients 2020, 12, 3044.

Kava as a Clinical Nutrient: Promises and Challenges
Kava beverages are typically prepared from the root of Piper methysticum. They have been consumed among Pacific Islanders for centuries. Kava extract preparations were once used as herbal drugs to treat anxiety in Europe. Kava is also marketed as a dietary supplement in the U.S. and is gaining...