Ok, I found the study.
http://www.sciencedirect....le/pii/S0031942203003819
From the summary, section 7
Based on the evidence discussed in this paper, the reason that kava lactones have been linked to hepatotoxicity is due to their dependence on the cytochrome P450 enzymes for clearance by the liver. The safe use of kava-kava has continued for many years and has been documented. In all traditional preparations of the kava root, the kava lactones are balanced by the availability of glutathione in the preparation. In the tablet and capsule forms of standardized extracts that relate to the reported cases of hepatotoxicity, only the kava lactones have been present in the products and no additional glutathione taken with the product.Based on the dosages reported to cause problems by the Medicines Control Agency (
Anon, 2001) and those reported by
Clough (2002), the only difference is the glutathione levels which would explain the differences in toxicity.
kavanah wrote
ics or it didn't happen.
rcoz wrote:
I can't remember, but wasn't there another study showing that the traditional method of perpetration provided enzymes to protect the liver from the adverse effects of kavain?
