Well, no I wouldn't say that kava doesn't have the potential for adverse reactions to certain medications or substances. However, I was only stating that we shouldn't be worried about the fact that kava has MAOI effects.Ahhhh, to be honest i'd had it in mind lately the possible interactions between different substances we would normally use in our daily lives in reference to kava; and that did create some concern (even though the natives have used kava for 3,000 plus years); but from what you've proposed by the substance just presented (Rasigiline) that concern is unwarranted, correct?
I'm not sure what you mean, but the issue of kava being potentially dangerous the average person due to its MAOI activity is next to nothing.And yes from that data it should be noted out of most substances that have adherence to being an mao/maoi or affinity to present receptors kava does not raise the red flags per se.
Sorry for not clarifying when saying that kava is more safe opposed to many substances just like you said we have to uphold a higher measure of concern; due in part and because of their stronger proclivities to mao or maoi property's; I hope that clears it up.Well, no I wouldn't say that kava doesn't have the potential for adverse reactions to certain medications or substances. However, I was only stating that we shouldn't be worried about the fact that kava has MAOI effects.
I'm not sure what you mean, but the issue of kava being potentially dangerous the average person due to its MAOI activity is next to nothing.
However, kava does have the potential to have adverse reactions with other medications, can aggravate some health conditions, and should always be consumed safely (from noble root only, using water) and you should always consult your doctor before starting any new substance, especially if you are taking other medications, have underlying health issues, history of health problems, genetic pre-dispositions to diseases, etc.
But this thread is about the MAOI activity of kava, and in that much, I can say it's safe to say that we don't have to take the same precautions that people on MAOIs have to (such as the strict dietary restrictions and such).
No worries Akava, I just got lost in the science.Thanks for all the responses,
I wasn't concerned about the MAO activity, the reason I was curious was because I was considering using kava to inhibit breakdown of PEA supplement
Selegiline has an IC around 8nm, kavalactons as you wrote 1200nm. When we drink 20g of Kava we drink 2g of Kavalactones together, and the dose of Selegiline is 10mg. So it does not come out that Kava is similar in MAO B power to Selegiline? Because it is dosed much higher. how to read it. Someone explainKeep in mind this was done in vitro, and the MAO-B inhibition was shown to be reversible which is much safer than irreversible MAOIs. Also, take into account the affinity of the ligand. Now, lower IC50 values will translate to higher affinity meaning more inhibition of MAOI-B.
"Kava-kava extract was found to be a reversible inhibitor of MAO-B in intact platelets (IC50 24 microM) and disrupted platelet homogenates (IC50 1.2 microM)"
Remember that the lower the number, the "stronger" the effect of MAO-B inhibition.
Take a Rx MAOI-B, for example, Rasagiline which shows an IC50 of 4.4 nM in humans. [http://www.scbt.com/datasheet-204875-rasagiline.html]
We have the IC50 value of kava (taking the lower of the two, just for illustration purposes) as 1.2 mM which translates to 1200 nM.
We can see the drastic difference with Rasagiline being extremely more potent in its antagonism/inhibition of MAOI-B and showing that while kavalactones possibly have some affinity for MAOI-B, it is not nearly close to the potency seen in prescription MAOIs.
Hope that makes sense and lays to rest any concern that anyone may have about MAOIs.