I got some ISA (I know, I know) from Root of Happiness. I was extremely nervous to try it for obvious reasons. I have a movement disorder (essential tremor, compounded by lithium treatment for mood disorder) that generally causes me quite a bit of disability. I'm already medicated for it, but it's still pretty bad). I had a very conservative 8 grams of the ISA and, while definitely much heavier than what I normally drink, it appears to have made the tremor disappear almost entirely. Other varietals were either no effect or aggravated it. In the interest of science and possibly to help others, I wanted to put it out there.