For reference, prednisone is an inducer of CYP450 enzymes, which means the effects of kava would probably be diminished if taken with prednisone in the system (kava inhibits CYP450). I often refer to
this drug interaction checker and go from there. I'm not sure what I would say on the interactions for someone else, but
@HerbalDude420 you have my most sincere sympathies.
I too am severely allergic to poison ivy. The last time I got it was from someone burning a brush pile sight unseen at least 50 yards from a walking trail, I could smell the brush fire in the air. Over the next couple days it began on my face and arms, then came out everywhere else. It must have blown right through my shirt, my whole upper body was one solid weepy poison ivy rash save a few splotches on my left side. Both of my eyes were nearly swollen shut, I looked like I'd come out of the losing end of a boxing match. I probably ate more benadryl that first week or so just trying to sleep away the misery than I had over the course of my whole life. I hope you are feeling better soon!