Several months ago I purchased 200g of GHK Moi Instant, and have been using it sparingly ever since. It's fantastic for a quick head boost, and very powerful. But it's also rather expensive, so I'd never done a full session with it. Since I was nearly out and the cultivar seemed great, I ordered Moi Instant, Micronized, and Medium Grind so I'd have a supply on hand.
With the typical kavahead attitude of "some is good, more must be great" I started a steady diet of Moi medium grind last Wednesday, using my normal prep. The day went well, and my somewhat increased energy level came in handy for the Holiday festivities. I continued drinking Moi exclusively, but
by Friday afternoon I was noticing an increase in anxiety, pulse and BP.
I attributed this to the change in schedule for the holiday, but was increasingly anxious (with a corresponding increase in BP) into and through Friday night. BP was still up this morning, so I started investigating what might be causing the effects. What I came up with is interesting:
Compared to my regular kava diet, Moi is quite high in yangonin:
Yangonin is not a kavalactone that gets much attention, so I looked it up. Here's what I found:
"
Yangonin is one of the six major kavalactones found in the kava plant. It has been shown to possess significant binding affinity for the cannabinoid receptor CB1. As a result of this cannabinoid receptor activity, yangonin may be responsible for some of kava's intoxicating effects. The CB1 agonist activity of yangonin mimics some of the psychoactive effects of THC. This, along with the GABAergic effects of other kavalactones has given kava a use in the ethnobotanical treatment of anxiety, insomnia, pain, and other disorders. This anxiety relief is unlikely to be contributed to Yangonin's CB1 agonistic properties as CB1 agonism is known to be anxiogenic rather than anxiolytic."
(Source:
http://en.wikipedia.org/wiki/Yangonin)
Is this the reason for my increased anxiety and BP? The kavalactone profiles of my regular kavas are very similar to Moi, with the exception of yangonin... Obviously not a scientific test in the slightest, but not psychosomatic either since I was expecting great things, and got less than great. I've had a couple of shells of Boronguru so far today (it is also low in Y, like my regulars), and am showing a decrease in BP and anxiety levels.
This is not intended to bring bad light on Moi at all, this is a fine noble kava, it just does not seem to work for me in the capacity I expected.
My intent for this post is to add another piece to the puzzle of how kavalactones affect us. I'll continue to monitor and report, but so far it looks like Moi needs to be an "occasional use" kava for me (where it is exceptionally effective), not a daily diet.
Garry