Oh, it makes a difference, alright. It makes a HUGE difference.
Here are some potential interactions between the drugs you listed:
- Zonisamide and Lamotrigine: these drugs are both antiepileptic medications, and may interact when taken together. This can lead to an increased risk of side effects such as dizziness, drowsiness, and decreased coordination.
- Clomipramine: this is a tricyclic antidepressant that can interact with a number of medications, including lithium, trazodone, and quetiapine. When taken with lithium, clomipramine can increase the risk of serotonin syndrome, a potentially life-threatening condition. When taken with trazodone or quetiapine, clomipramine can increase the risk of QT prolongation, a type of abnormal heart rhythm.
- Lithium: this is a mood stabilizer that can interact with a number of medications, including clomipramine, trazodone, quetiapine, and primidone. When taken with clomipramine, lithium can increase the risk of serotonin syndrome. When taken with trazodone or quetiapine, lithium can increase the risk of QT prolongation. When taken with primidone, lithium can increase the risk of neurotoxicity.
- Trazodone and Quetiapine: these are both medications used to treat mood disorders and may interact when taken together. This can lead to an increased risk of side effects such as dizziness, drowsiness, and decreased coordination.
- Primidone: this is an anticonvulsant medication that can interact with lithium. When taken with lithium, primidone can increase the risk of neurotoxicity.
- Omeprazole: this is a proton pump inhibitor that can interact with some medications, including levothyroxine and propranolol. When taken with levothyroxine, omeprazole can decrease the absorption of levothyroxine, potentially reducing its effectiveness. When taken with propranolol, omeprazole can increase the concentration of propranolol in the blood, potentially increasing the risk of side effects.
- Levothyroxine: this is a medication used to treat thyroid disorders that can interact with omeprazole. When taken with omeprazole, levothyroxine can be less effective because omeprazole can decrease its absorption.
- Propranolol: this is a medication used to treat high blood pressure and other conditions that can interact with omeprazole. When taken with omeprazole, propranolol can be more concentrated in the blood, potentially increasing the risk of side effects.
This is without even mentioning kava. Needless to say, you've got a quite a story to unravel even before you begin to consider kava. Talk to you doctor about the list of drugs you're taking, and ask them if there are any known side effects with taking them together. Start there, and work your way out. With that number of drugs there isn't a pharmacologist on earth that can tell you how kava might be interacting. I'm personally surprised you don't get double-vision without any kava at all.