I'm glad of this thread. Last night, after chugging some Pouni Ono, I ever so gradually slumped into an unpleasant, vaguely desolate, place mood wise. It had happened before with Kava, so I'm recognising a pattern. It's true I'm not thriving these days and struggle to find purpose since I stopped working, so yeah I'm probably a bit depressed. But I was surprised by how low I got just a few hours after a couple of shells.
I have some Mucuna Pruriens but never felt anything after taking it. Perhaps I need to persevere.