A relatively new paper observed glycine receptor inhibition by kavain, it is as if very mild strychnine. Should be a body stimulant.
Very weak CB1 agonism of yangonin paired with its glycine agonism sounds unique indeed.
It seems to be a two-edged sword for liver as it is a hepatoprotectant and hepatotoxin at the same time.
I have not put too much time to studying 60+ abstracts available in PubMed tackling yangonin, though.
Roots of kava (Piper methysticum) plant are used in almost all Pacific Ocean cultures to prepare a drink with sedative, anesthetic and euphoric properties. One of the main active ingredients of the extract are kava lactones. Here, kava root CO2 extract and three kavalactones, DL-kavain...
pubmed.ncbi.nlm.nih.gov