"Pharmacological studies on the sedative and hypnotic effect of Kava kava and Passiflora extracts combination" A. Capassoa L. Sorrentino
Abstract:
"Kava kava extract, Passiflora extract and a combination of both extracts, administered to mice, caused a significant
decrease of the amphetamine-induced hypermotility and significant prolongation of sleeping phase induced by
subcutaneous injection of barbiturates. Due to a synergism of both extracts, simultaneously administered the
pharmacologically registered effect in both in vivo experiments was found to be superior over the sum of the single
separately administered extracts"
Conclusion:
"The quantitatively assessed effect in the pharmacological test shows an approximately 50% higher efficacy of the combination passiflora/kava in comparison with the single substances. In case of the barbiturate sleeping time the effect of the combination is as well approximately 50% higher compared with the single substances."
Abstract:
"Kava kava extract, Passiflora extract and a combination of both extracts, administered to mice, caused a significant
decrease of the amphetamine-induced hypermotility and significant prolongation of sleeping phase induced by
subcutaneous injection of barbiturates. Due to a synergism of both extracts, simultaneously administered the
pharmacologically registered effect in both in vivo experiments was found to be superior over the sum of the single
separately administered extracts"
Conclusion:
"The quantitatively assessed effect in the pharmacological test shows an approximately 50% higher efficacy of the combination passiflora/kava in comparison with the single substances. In case of the barbiturate sleeping time the effect of the combination is as well approximately 50% higher compared with the single substances."
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